The Oklahoma Highway Patrol says meth was leaking down Davis Williams' leg as he tried to run away from a trooper just after midnight.
The trooper had stopped an SUV for speeding on 221st Street South in Okmulgee County.
After giving the driver a ticket, the trooper began to question the passenger, Davis Williams, about a chemical smell.
The OHP says Williams, 54, then took off running, but the trooper caught him and a struggle ensued.
"After a brief struggle it was determined there was an active meth lab in his pants that burst during the struggle and got all over his body," said OHP trooper Shiloh Hall.
Medical personnel checked out Williams and the road was closed so emergency crews could clean up the scene.
Williams was booked into the Okmulgee County jail on a complaint of manufacture of a controlled and dangerous substance. The driver of the SUV was not arrested.
The OHP says the driver was taking Williams to his semi at the time of the incident.
A portable meth lab is also known as a one-pot lab, where a smaller batch of the drug is manufactured.